OBJECTIVES: The aim of this study is to evaluate the relation between the Clinical Risk Groups (CRG) classification system and health-related quality of life (HRQOL). METHODS: An observational, descriptive and cross-sectional study. The sample of the study was 306 patients over 18 years after applying exclusion methods to 921 people randomized from 32,667 patients of Health District 2 of Valencia Community. HRQOL was measure using three-item EQ-5D instrument and multimorbidity in 9 health statuses of CRG. Spearman correlation between CRGs classification and EQ-5D dimensions and index score was performed. RESULTS: HRQOL pain/discomfort is the higher dimension affected (53%). By CRG main health status, physical health deteriorated more than mental health with increasing multimorbidity: Anxiety/depression is the higher dimension affected (30%) in first and third health statuses (43%) and pain/discomfort is the higher dimension affected in the other statuses except the ninth state which has in general greater affectation in all dimensions. EQ-5D index score average by CRG status were: healthy 1 (0.9270), health status 2 (0.8669), health status 3 (0.8075), health status 4 (0.7713), health status 5 (0.7472), health status 6 (0.5763), health status 7 (0.5967), health status 8 (0.5947) and health status 9 (0.4854). CONCLUSIONS: In primary health care severity health status are related to low values of HRQOL, being higher in women under 65. This model enables the identification of patients’ needs by morbidity.