OBJECTIVES: To evaluate the therapeutic indication of 40mg/m and 125mg/ml injectable suspension (IV) methylprednisolone in the treatment of people with idiopathic thrombocytopenic purpura. METHODS: A literature search was carried out on February 04, 2015 in the following databases: BMJ - Best Practice, Dynamed and UpToDate. It was chosen to use evidence synthesis databases due to the fact that it is a medical issue which daily brings new information on the subject and it enables to recover the original information examined, commented and evaluated critically, according to the methodology recommended by clinical epidemiology. The search strategy adopted the vocabulary of structured Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) to better identify the references of interest. Indexed terms used in the research were: "Purpura, Thrombocytopenic, Idiopathic" and "Methylprednisolone." RESULTS: According to the evidence located in BMJ the use of corticosteroids (methylprednisolone) is indicated as first-line treatment in patients with idiopathic thrombocytopenic purpura in some situations. According to the located in Dynamed, the use of high doses of methylprednisolone (oral 30 mg/kg/day for 3 days plus oral 20mg/kg/day for 4 days) is indicated as second-line therapy for the treatment of patients with persistent or chronic idiopathic thrombocytopenic purpura. Since the evidence synthesis found in UpToDate showed that for treatment of patients with serious bleeding and platelet count <30,000/microL it is recommended the immediate use of platelet transfusion, intravenous immunoglobulin or 1g intravenous methylprednisolonefor 3 days. CONCLUSIONS: According to the presented syntheses, there is not enough evidence about the use of methylprednisolone in treating people with idiopathic thrombocytopenic purpura. Thus, we do not recommend the inclusion of 40mg/mL and 125mg/ml injectable suspension (IV) methylprednisolone in RENAME 2016, being maintained only the 500mg injectable lyophilized powder pharmaceutical form.