OBJECTIVES:  To investigate the determinants of the impact of the economic crisis on general and oral health in the greater area of Athens, Greece. METHODS:  A non-randomized, cross-sectional, observational study of 463 dental patients in the greater area of Athens between March and April 2014. Patients were enrolled from 5 private dental clinics and completed a self-administered questionnaire collecting data on socio-demographics, self-rated general and oral health status, oral and general health-related quality of life, while a 5-point self-evaluation of the magnitude of the impact of the economic crisis on their oral and general health was also used. Descriptive statistics and binary logistic regression models with backward elimination of poor predictors were employed to determine the most important factors influencing the health impact of the economic crisis. RESULTS:  60.1% and 54.6% of the sample reported an impact of the economic crisis on their general and oral health (p=0.007). Females, older age, lower education and income, and unemployment were associated with higher reported health bearing on both general and oral health. A year increase was associated with 14% (p<0.001) and 3.3% (p<0.001) increased odds of recording an impact on oral and general health, respectively. Participants of the highest income class were 82.3% (p=0.001) και 72.9% (p=0.010) less likely to report an impact on their oral and general health, respectively, than those belonging in the lowest. CONCLUSIONS:  The economic crisis exerts a significant health impact on Greek citizens, which appears to be marginally higher on general compared to oral health. Lower age and higher socio-economic status, as it is measured by income, exhibit a protective function against the health aggravating effects of the economic crisis in both general and oral health status.