OBJECTIVES: Pelvic girdle and low back pain (PGLBP) is a common condition during pregnancy, resulting in poor functional score and quality of life. Its economic burden is mostly explained by indirect non-healthcare costs caused by work-time lost. Our objective was to assess the cost-effectiveness of acupuncture care services for PGLBP during pregnancy. METHODS: The GAME pragmatic-open-label trial randomized 1:1 pregnant women with PGLBP from five Paris region maternity between 2012 and 2014 to receive standard care or standard care plus acupuncture (5 sessions performed by an acupuncturist midwife). The primary efficacy outcome was proportion of days with self-assessed pain <4/10. The main cost effectiveness outcome was incremental cost per day without pain. Indirect non-healthcare costs included daily compensations for sick leave and productivity loss caused by absenteeism or presenteeism. RESULTS: