OBJECTIVES: Clinical pharmacy program recently started at the Private Hospital in Saudi Arabia. Dr. Sulaiman Al Habib Medical Group is one of the biggest private hospitals in Riyadh city. Clinical pharmacy program began at critical care units in 2015. The objective of the study to assess the clinical and economic outcomes of pharmacist intervention at critical care units at private hospital in Riyadh city, Saudi Arabia METHODS: It is the cross-sectional study of one month-2016 in adults and pediatrics critical care clinical pharmacist. The pharmacist monitored all patients on the daily basis through a medical round and documents any intervention. The pharmacist intervention system used an International Study Model (Kinky et al., Ann Pharmacother 1999), measure level of activity, rational of clinical intervention, recommendation, patient outcome and PharmacoEconomic impact. The estimated cost valuation expressed in USD. RESULTS: The total number of pharmacist interventions were 114. Of those 70 (61.4%) was male, 44 (38.6%) was female. The majority of them in age 65 and above was 59 (51.75%) followed by age 18-40) was 30 (26.32%). The Most drug classification had interventions was Anti-infective drug 37 (32.46%) followed by cardiovascular medications 26 (22.81%). The highest interventions were potentially serious 70 (61.4%) and potentially significant 31 (27.19%). The rationale of intervention was inappropriate dose 18 (15.79%), drug therapy omission 16 (14%), and alternative therapy 10 (8.77%). The most patient outcome was therapeutic end point reached 52 (45.61%) and patient condition improved 27 (23.68%). The most PharmacoEconomic impact was the reduction in cost drug therapy 54 (47.37%). The estimated cost avoidance (33,711.84 USD), the total annual estimated cost avoidance (404,542.1 USD) CONCLUSIONS: The clinical pharmacist at critical care units of the private hospital is crucial and essential. The pharmacist prevents drug-related problems and saving an additional cost of pharmacy services and health insurance system