OBJECTIVES:  Medically attended acute gastroenteritis (MAAGE) is due to multiple causes including viruses, bacteria and parasites. The objective was to assess the episode rates of MAAGE to inform the cause-specific MAAGE burden of disease. METHODS:  Patients registered in general practices contributing to Clinical Practice Research Datalink (CPRD) from January 2006 to December 2014 and eligible for Hospital Episode Statistics (HES) Inpatient linkage data were included. Cases were defined based on MAAGE related Read and ICD-10 codes. Episodes were defined as events separated by a minimum 14-day disease-free period. Episode rates with 95% CIs were calculated by calendar year and month, age group (<1, 1-4, 5-9, 10 -17, 18-64, 65-74, 75-84 and 85+ years old), gender, region, healthcare setting (GP care only or requiring hospitalization) and aetiology. RESULTS:  A total of 5 124 812 subjects (50.9% female) were included in the study with a median follow-up time in CPRD of 7.6 years. 273 774 cases were identified with at least one MAAGE episode, representing an overall episode rate of 12.95 per 1000 person-years (95%CI: 12.90-12.99). The highest burden was observed in <1 years old, 1-4 years old, and 85+ years old, with episode rates of 95.57 (94.38-96.76), 39.26 (38.89-39.62) and 36.02 (35.56-36.49) respectively. Episode rates were stable year-on-year with marked winter seasonality. Episode rates requiring GP care only vs. requiring hospitalization were 7.43 (7.40-7.47) and 5.52 (5.49-5.55) respectively. The episode rate with aetiology unspecified was 11.81 (11.77-11.86) CONCLUSIONS: Burden of MAAGE is high in the CPRD population with the highest episode rates in children and elderly. In order to assess cause-specific burden of MAAGE further statistical modelling development is required to attribute the high proportion of cause-unspecified MAAGE. ISAC protocol 16_063R.