OBJECTIVES:  Rheumatoid arthritis (RA) has a substantial negative impact on patients’ lives and is associated with pain, reduced mobility, and extraarticular comorbidities, including anxiety and depression. In the present study, patient-reported anxiety/depression were described, and the association of anxiety/depression with disease activity, disability, and satisfaction with current treatment were characterized. METHODS:  Mood disorder data were drawn from the 2014 EU5 and US Adelphi RA Disease Specific Programme. Patients reported the presence of anxiety/depression using the EQ-5D anxiety/depression domain in the Patient Self Completion form. Multivariate models (controlling for patient age, gender, body mass index, and current disease severity) were used to evaluate the correlation between anxiety/depression and the following measures: percent overall work impairment using the Work Productivity and Activity Impairment (WPAI) questionnaire, Health Assessment Questionnaire-Disability Index (HAQ-DI), and 28-joint Disease Activity Score (erythrocyte sedimentation rate [DAS28[3](ESR)]) (all evaluated by linear models), and patient satisfaction with current treatment (evaluated using logistic regression). Across these analyses, the number of patients with available data varied. RESULTS:  38.4% of patients reported moderate (n=349) or extreme (n=41) anxiety/depression as their current health state (n=1,015 in the analysis). Patients reporting moderate or extreme anxiety/depression had greater work impairment, higher HAQ-DI and DAS28[3](ESR) scores, and a higher likelihood of current treatment dissatisfaction than those reporting no anxiety/depression (all P<0.001). Multivariate analysis highlighted significant differences between patient-reported moderate anxiety/depression and higher WPAI scores, higher HAQ-DI scores, and lower patient-reported satisfaction with current treatment (all P<0.001); there were also significant differences between patient-reported extreme anxiety/depression and worse DAS28[3](ESR) (P=0.004) and HAQ-DI (P<0.001) results, along with patient-reported satisfaction with current treatment (P=0.001), all compared to patients without anxiety/depression. CONCLUSIONS:  Anxiety and depression represent a significant burden for patients with RA. The findings of this study highlight the multi-dimensional impact of anxiety and depression as key extraarticular comorbidities of RA.