DESCRIPTION:  The ISPOR tool – Pharmacoeconomic Guidelines Around the World - features a listing and description of international official guidance regularly shaping formulary decisions. The periodic review of guidelines raises a few questions, such as-- What are the methodological challenges and political contestation involved in the establishment, review and use of the guidance. This forum will therefore explore the latest controversies regarding national health economic evaluation guidelines in the context of southern European regions via a moderated debate among experts. In doing so, this session seeks to provide analytical insight for analyzing and revisiting the national guidelines presented.