OBJECTIVES: To describe the trends in published comparative cost analyses from 2010 through 2012 for interventions in cancer (CA), diabetes (DM), and cardiovascular diseases (CVD). METHODS: A PubMed search of articles published between January 2010 and December 2012 was conducted utilizing the following search strategy/terms: (cost-effectiveness OR cost-utility OR cost-benefit) AND (cancer OR diabetes OR cardiovascular diseases).  Articles were excluded if they: 1) did not contain sufficient information to determine the type of analysis conducted; 2) focused on a sequelae of a treatment; 3) no comparative analysis was conducted; 4) only costs were considered; or 5) were reviews, editorials, or commentaries. The abstracts of the articles, not the full articles themselves, were evaluated and used to classify comparative economic analyses by disease focus, intervention type, intervention target (e.g., treatment, prevention), economic analysis performed, geographic region of population/perspective of the analysis, and primary/corresponding author affiliations.  Descriptive statistics were conducted in PASW Statistics 18.0.  RESULTS: The initial search yielded 3,868 abstracts.  Of these, 725 studies were retained in the final analysis (254 in 2010, 226 in 2011, 245 in 2012).  In 2010, 2011 and 2012, respectively, 134, 119, 150 studies were in CA, 25, 23, 35 in DM, and 95, 84, 60 in CVD.  Approximately 63.7% of studies across years focused on active treatment or secondary prevention. A pharmaceutical, vaccine, or lifestyle intervention was the focus in 47.9% of studies.  A majority (70.2%) of the studies utilized cost-utility analyses, which was consistent across all years, with most study populations/study perspective in European countries. CONCLUSIONS: Comparative economic analyses from 2010-2012 had a heavy focus on active or secondary interventions in CA and in European populations.  As value-based pricing and health care reform emerges, more extensive utilization and publication of comparative cost effectiveness analyses will be required.