OBJECTIVES: Atopic dermatitis (AD), also known as eczema, is a common chronic skin condition in childhood that has negative impact on both patients and their families. A survey was conducted to evaluate the disease burden, financial and quality of life impact of moderate to severe AD across 12 countries in the Asia Pacific region. In this analysis, we examine the disease burden of pediatric AD by country.  METHODS: A cross sectional survey was conducted in Australia, China, Hong Kong, India, Indonesia, Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand, and Vietnam in January, 2011. An online questionnaire was administered to 1028 parents with children diagnosed with moderate to severe AD (aged 1 t- 16 years). For the purpose of analysis, respondents were categorized according to country, disease severity based on the Nottingham Eczema Severity Score, and age group. RESULTS: In the population sampled, there were 27% infants (aged less than 4 years) and 73% children (4 - 16 years old). Approximately 60% of the respondents from all countries reported moderate AD. Infants and children with moderate AD experienced fewer flare-ups per year (median=5) compared to children with severe AD (median=7). There was no difference in overall flare-up duration (5 days) between moderate and severe AD. The overall percentage of children with more than 6 flare-ups per year was 41%, more often seen in (≥45%) in Singapore, Australia, Thailand, Taiwan, and Hong Kong. Common associated conditions with AD were food allergies, asthma and rhinitis.  CONCLUSIONS: Results of the survey showed that moderate to severe AD is a common condition affecting infants and children with an average of 5-7 flare-ups per year lasting an average of 5 days. The burden of AD is higher among more developed countries in the Asia Pacific region.