OBJECTIVES: Pseudoephedrine (PSE) is used as a precursor in the illicit production of methamphetamine. Policies that restrict the sales of PSE have been adopted to curb production, which causes chemical and thermal burn injuries that create cost and treatment burdens on the health care system. The purpose of this project is to estimate the relationship between burn injuries and PSE sales. METHODS: PSE sales data from the National Precursor Log Exchange were merged with hospital discharge data from the Kentucky Cabinet for Health and Family Services Office of Health Policy Public Use Data Set.  Kentucky residents with a primary diagnosis of burn (ICD-9 940.0-949.5) in 2010 were included. A negative binomial regression was performed with number of burns per county as the dependent variable. The primary explanatory variable was PSE sales per county (in grams/100 residents). Control variables included: % high school graduates over 25, urbanicity, and unemployment, all adjusted by county population. RESULTS: In 2010, 340 burns were treated in Kentucky facilities with 33 counties having no burns and 94% of counties having 6 or fewer burns.  Mean PSE sales were 49 g/100 county residents (SD=39), with a range of 0.3 g to 147 g per 100 county residents. A 1 gram increase in PSE sales per 100 residents was associated with an increase of approximately 1.1 burns per county (p<0.001). Controlling for population, urban counties had more burns than rural counties (p=0.004) and counties with higher percentages of high school graduates had fewer burns (p<0.001).  Results were robust to various dispersion settings. CONCLUSIONS: These results suggest that PSE sales are associated with burn injuries. Limitations include missing data on cross-border PSE sales and the inability to distinguish methamphetamine-related burn injuries from other burns. These findings suggest that additional PSE sales restrictions may reduce the number of burn-related discharges.