OBJECTIVES: To explore the prevalence, diagnosis & treatment protocol of breast cancer in patients treated at Bahawalpur institute of nuclear medicine and oncology (BINO).  METHODS: A retrospective study was carried out on the data from the treatment records of patients (n = 300). Patient age, education status, involved breast, type & stage of disease at diagnosis, socioeconomic status of patients & metastasis in patients as well as the treatment protocols was evaluated. Statistical tools were applied for analysis.  RESULTS: The mean age of patients was 48 ±15 & 92% patients were illiterate. Infiltrating ductal carcinoma (IDC) 96% was the most common type of breast cancer found in population and were mostly diagnosed at Grade 3 (69%). Most of the patient had carcinoma of right breast (53%) while about 43% had of left breast. Patients with breast cancer were mostly married (99%) & patients were belonging to poor socioeconomic status. Diagnostic tests performed for most of the cancer patients were mammography, biopsy, USG, X-ray & MUGA & bone scan and about 60% of the population had undergone mastectomy.  CONCLUSIONS: Infiltrating ductal carcinoma (96%) was found the most common type of breast cancer in southern Punjab. The socioeconomic status of the patients might affect the prevalence of breast cancer in patients