OBJECTIVES: Pharmaceutical companies have designed prescription drug coupons and copay cards (CCCs) programs to maintain brand name medication loyalty, especially for medications that have just, or are about to lose their patent. The objective of this study is to evaluate perceptions of retail pharmacists about coupon and copay card (CCC) programs. METHODS: Pharmacists in the state of Arkansas, USA, were surveyed online. Questions on 5-point likert scale focused on pharmacist’s perceptions towards CCC's regarding benefits to patients, public health, medication compliance, pharmacist workload, as well as barriers to pharmacy practice. Chi-square and multivariate logistic models were used to analyze the data. RESULTS: Of the approximately 1200 subjects 325 took the survey. Excluding missing values, 214 subjects were included in final analysis. Of these, 56% were male, 47% were less than 35 years of age, and 46% worked in a franchise or chain pharmacy, 40% were located in urban or suburban areas, 60% were in semi-urban or rural areas. Regression results indicated that full-time pharmacist practicing in larger pharmacies and processing higher numbers of CCCs had more favorable views towards patient satisfaction with CCCs (all p-values<0.05). Most pharmacists were reluctant to express that CCCs saved patients money, were good for public health, or improved medication compliance.  Most pharmacists agreed that CCCs increased pharmacy workload, however highly satisfied pharmacist with proper staffing disagreed.  Female pharmacists were more likely to explain CCC use to patients.  Pharmacists working in high-volume chain and urban environments were least likely to state difficulties processing CCC transactions. All p-values in regression results reported above were <0.05 with odds ratios ranging from 1.05 to 2.5 (note: individual p-values and odds ratios are too many to report because of word limit). CONCLUSIONS: With increasing prevalence of CCCs, this study provides key insights into perceptions of pharmacists.