OBJECTIVES: The WHO with its MPOWER (Monitor Protect Offer Warn Enforce Raise) program is assisting the Kingdom of Saudi Arabia (KSA) one of the top 10 cigarette importing countries with a 29% reported smoking prevalence among college Students. This study determined predictors of willingness to quit smoking among a cohort of Saudi male college students. METHODS: A cross-sectional study was conducted in a cohort of male (≥18 years) college students that were recruited from three higher education institutions located in two regions within KSA. A pre-tested valid survey was used to collect data including socio-demographics, addiction level, presence of a smoker within the family, social pressure to quit, and number of past attempts to quit. The willingness-to-quit variable was defined by asking participants if they had seriously thought about using smoking cessation strategies. Bivariate and logistic regression analyses were performed to assess factors associated with willingness to quit smoking.   RESULTS: About 467 surveys were received (response rate 51%). Around 30% (n=104) of participants were smokers of which 72% (n=75) indicated their willingness to quit smoking. The average age of those willingness-to-quit was 22.6 (±2.2) years with an income of