OBJECTIVES: The health related quality of life (HRQoL) among hypertensive patients is influenced by a number of factors. However, there is paucity of information on the determinants of HRQoL among hypertensive patients particularly from developing countries such as Pakistan. This study therefore aims to describe the predictors and correlates of HRQoL in a hypertensive population of Pakistan. METHODS: A questionnaire based, cross sectional study was conducted among 385 hypertensive patients visiting two public hospitals in the city of Quetta, Pakistan. Demographic and disease related data was obtained from the patients and their hospital records. The generic EQ-5D questionnaire was used to measure HRQoL while Drug Attitude Inventory and Hypertension Fact Questionnaire were used to measure medication adherence and hypertension related knowledge respectively. Scale scores were compared with Mann-Whitney and Kruskal-Wallis test. Spearman's rho correlation was used to envisage the correlates of HRQoL. Standard multiple regression analysis was performed to identify predictors of HRQoL. RESULTS: Patients in the current study reported poor HRQoL with mean score of 0.46±0.28. In terms of practical implementation, age (β=0.298, p<0.001), educational level (β=0.493, p=0.025) and knowledge score (β=0.351, p=0.024) reached level of significance in the multivariate analysis. The multiple regression analysis also found that variables like gender, occupation, income, locality, duration of disease and medication adherence were not significantly associated with HRQoL.  CONCLUSIONS: The results of the present study provide an evidence for a model that correlates with patients’ socio-demographic information and HRQoL. The findings after implication in clinical practice can prove useful in guiding patients receiving treatment for HTN. It will also help the physicians to maintain and adjust treatment behaviours with drug or non drug related interventions.