OBJECTIVES: To analyze the effectiveness of a multicomponent home-based environmental asthma intervention targeting children from low income families in East Harlem, New York City. METHODS: Three hundred eighty children aged 17 years or younger with asthma participated in the study. These children and their families were assessed for baseline characteristics including asthma symptoms and health care utilization experienced by a child; presence of home environmental triggers; and parents’ knowledge and skills in managing the child’s asthma. Based on baseline characteristics, families that received environmental intervention (n=200) were compared with those that did not (n=18). The main asthma outcomes were rates of emergency department visits (edv), hospitalizations (hsp), asthma symptom days (asd), school days missed (sdm), and work days missed (wdm) due to asthma. Observable variables included age, gender, race, and baseline rates of edv, hsp, asd, sdm, and wdm. The effect of the intervention was measured as the difference in the main asthma outcomes at the baseline and at post-intervention assessment. To reduce the influence of confounding factors we applied  propensity score method to estimate effect of the intervention on the main asthma outcomes.  RESULTS: Baseline main asthma outcomes were: 2.56 (intervention group) and 2.64 (control group) for edv, 0.44 and 0.62 for hsp, 7.35 and 5.86 for asd, 5.38 and 6.96 for sdm, and 6.95 and 3.57 for wdm. The average treatment effect of the intervention was 2.13 for edv, 0.92 for hsp, 2.67 for asd, 1.95 for sdm, and 1.89 for wdm. All estimates, except hospitalizations, were significant. The unmatched outcomes for the same outcomes were 3.36, -0.17, 3.80, 1.66, and 1.48 respectively.   CONCLUSIONS: The results of the study suggest that low-income families can benefit from the intervention by reducing emergency department visits, asthma symptom days, and missed school and work days.