OBJECTIVES: The objective of this study is to quantify utilities loss in men and women affected by HPV-induced pathologies in Italy. METHODS: A multicentre, retrospective study was designed to enroll a cohort of males and females with HPV-related diseases who were detected and managed in the preceding 18 months. Utilities were calculated using the Time Trade-Off (TTO) method. The elicitation of utilities was performed using a validated algorithm [Mennini et al. Clin Ther 2011 ] specifically developed to the computer-guided and standardized administration of a TTO questionnaire. Utilities associated with each of the following pathologies were assessed: atypical squamous cells of undetermined significance (ASCUS), cervical intraepithelial neoplasia (CIN) grade 1, CIN grade 2-3 and cervical cancer in women; anogenital warts, anal cancer and head and neck cancer both in men and women. The European Quality of Life questionnaire (EQ-5D) was used to assess the baseline health conditions of respondents.RESULTS: On 450 enrolled patients, 421 (mean age 44.9±16.5 years) responded, providing an overall response rate of 93.6%. The patients’ perception of their health state was rather high (EQ-5D score ranged between 1 and 0.8), with the exception of patients affected by anal cancer patients (EQ-5D corresponding to 0.6±0.3). The mean utility value by HPV-induced pathology corresponded to 0.77±0.27, 0.71±0.29, 0.83±0.22, 0.81±0.27, 0.58±0.31, 0.51±0.26 and 0.69±0.30 for ASCUS, CIN1, CIN2-3, invasive cervical cancer, anogenital warts, anal cancer and head and neck cancer, respectively. The regression analysis showed that only the pathological condition influences the estimated utility value. CONCLUSIONS: Patients' health-state preference is a variable with a high impact on economic evaluations. The measurement of each utility relied on a solid and well recognized procedure. This multicenter study elicited utilities in a wide range of HPV-induced pathologies and in a large sample size as well.