OBJECTIVES: Pseudoephedrine (PSE) is used as a precursor in the illicit production of methamphetamine. Several policies have been adopted to control access to PSE, including tracking of sales, quantity restrictions and, in two states, the reclassification of PSE as a Schedule III controlled substance. In 2012, the Kentucky Legislature considered a controversial bill proposing the reclassification of PSE as a legend drug available by prescription only. The purpose of this study is to assess physician opinion of the proposed legislation.   METHODS: A simple random sample of 2000 licensed physicians in Kentucky were mailed a survey that solicited opinions on the proposed PSE legislation. Non-responders were contacted via reminder postcards twice between June and July of 2012 and were offered the option to complete a survey electronically. Response frequencies were calculated and logistic regression was used to analyze the impact of physician characteristics such as confidence in the ability to identify legitimate PSE use, practice type, urbanicity, legislation awareness, and estimated frequency of PSE demand on likelihood of PSE legislation support. RESULTS: Excluding bad addresses, 243 surveys were returned (response rate=12.5%). Physician support for legislation to reclassify PSE as a legend drug was mixed, with 41.3% in support, 40.5% in opposition and 18.2% unsure. Physicians supporting the legislation most commonly cited reduced risk of methamphetamine abuse (55.5%) as reason for support.  Physicians who reported being confident in their ability to identify legitimate PSE use were more likely to express support (p=0.026), as were those reporting low estimated requests for PSE during peak allergy/flu season (p=0.002). Physicians in urban counties were less likely to express support (p<0.001).   CONCLUSIONS: These findings suggest that Kentucky physicians are divided on the issue of PSE reclassification and that physician characteristics influence opinion. The potential impact on physician behavior should be considered when evaluating PSE policy options.