OBJECTIVES: This study aimed to assess the association of Crohn’s disease prevalence with demographic characteristics in the U.S. veteran population. METHODS: This study analyzed a patient sample from the Veterans Health Administration (VHA) Medical SAS datasets from October 1, 2005 to May 31, 2012. All patients diagnosed with Crohn’s disease during 2011 were identified using International Classification of Disease 9th Revision Clinical Modification (ICD-9-CM) diagnosis code 555. Patients with medical benefits enrollment not covering 2011 were excluded. Study patient demographic information was then captured and categorized into groups. All descriptive statistical analyses were performed using SAS v9.3 software. RESULTS: For VHA patients diagnosed in 2011 with Crohn’s disease (N=41,418), prevalence varied by race as follows: Non-Hispanic White (0.23%), Non-Hispanic Black (0.14%), Hispanic (0.09%) and other races (0.13%). When stratified by age, the highest prevalence was observed in the higher age groups: 55-64 (0.21%), 35-54 (0.20%), and 65+ (0.17%). Based on the examination of Crohn’s disease prevalence in different states, the disease was found to be most likely diagnosed in Maine (0.35%), Vermont (0.29%), Connecticut (0.28%) and New Hampshire (0.24%). On the contrary, Puerto Rico (0.07%), Washington D.C. (0.07%) and Hawaii (0.06%) showed the lowest prevalence. However, the difference was never greater than 0.3%. CONCLUSIONS: The uneven distribution of Crohn’s disease among U.S. states suggests a geographic variation in risk areas that may be useful for future targeted intervention strategies.  Further research may be necessary for middle-aged and elderly patient groups to prevent this disease.