OBJECTIVES: To evaluate the consistency of information given in drug brochures by pharmaceutical companies METHODS: Total of 500 drug brochures were collected from the doctors’ clinics in Pakistan and 473 brochures were collected from the general practitioners’ clinics in Malaysia. After comprehensive scrutiny, a total of 498 brochures were included and evaluated for the study. An evaluation form was developed based on the criteria given by WHO, FIPMA, DCOMOH(Pakistan) and PhAMA. The data was analyzed using SPSS. To summarize the data, descriptive statistics (frequencies, percentages,) were calculated and Chi-square test and Fisher’s exact test were applied as inferential statistics. A Pvalue of less than 0.05 was considered as statistical significance for all the tests. RESULTS: The Cronbach’s coefficient Alpha value was 0.729 (n=50). The study found that the dosage form was presented significantly (P=0.009) less in national companies’ (NCs) brochures as compared to MNCs.  MNCs were found significantly adherent to the standard criteria for brochures as compared to NCs for presenting drug interactions (P<0.001), precautions (P<0.001) and expected ADRs (P<0.001). National companies were found significantly (P<0.001) adherent to the standard criteria in terms of presenting contraindications and warnings. MNCs were significantly better (P=0.009) in terms of including contact information in the brochures. A significantly higher number of Malaysian brochures providing information about drug interactions (P<0.001), precautions (P<.001), expected ADRs (P<0.001) and contraindications (P<0.001). On average 3 (median, IQR=5) references were used in the brochures out of which on average 2 (median, IQR=6) references were understandable. The references having enough information to access particular study were considered understandable. CONCLUSIONS: The drug information given in the brochures, discrepancies are observed mainly in drug safety related information like side effects, possible ADRs, precautions etc. The references cited in the brochures were also found to be inappropriate and incomplete.