OBJECTIVES: This study tried to find out whether the level of knowledge and skills of people working in a community pharmacy and applying strategy planning in community pharmacies, in Iran, can affect  their achievements, as small to medium sized enterprises working in a circumstance with little professionalization of community pharmacies activities.  METHODS: In 2015, a cross-sectional survey was conducted using self-administered, anonymous questionnaires designed for managers, pharmacy staff, and pharmacy clients. The target population of this study was community pharmacies settled in Tehran, the capital city of Iran. The managerial team of the invited pharmacies must remain unchanged for at least three years ending to the study. Manager’s and staff questionnaires contained questions about their job satisfaction, self assessment of knowledge, skills, and performance. Staff was also asked about manager’s behavior. Client’s questionnaire evaluated client’s satisfaction with the pharmacy. Confirmatory factor analysis and correlation test were performed using SPSS 16.0.0. RESULTS: Data from 187 pharmacies was gathered. Based on the results, applying strategy planning had significant relationship with financial (R=0.204, p-value<0.05) and societal results (R= 0.451, p-value < 0.01). Manager’s behavior was significantly (p-value < 0.01) correlated with society, staff and client result (R= 0.234, 0.674 and 0.307, respectively). Staff’s knowledge and skills was related with staff’s satisfaction (R=0.211, p-value < 0.01), society (R=0.339, p-value < 0.01) and financial (R=172, p-value < 0.05) result, but client’s satisfaction correlation was only significant with technical pharmacist’s skills (R=0.275) and non-pharmaceutical knowledge (communication, information exchange, and ethics) (R=0.301). CONCLUSIONS: Although community pharmacies, in Iran, suffer from low professionalization and health policy makers’ inattention, results of this study are promising, because show that manger’s can still affect pharmacy achievements by improving their behavior, knowledge and skills.