OBJECTIVES: To study the effect of stress and coping resources on predicting graduate students’ quality of life measured by the WHOQOL-BREF. METHODS: A battery of “Stress and Coping Resources” for graduate students was developed through a standard psychometric process. Four subscales are for Stress: relationship with advisor, future development, academic difficulty, and livelihood. Two scales are for Coping Resources: academic potential (knowledge, moral/ethic, resilience/endurance, self-management, and teamwork) and interpersonal relationship (with family, friends, peer, and intimacy partner). In addition, the WHOQOL-BREF questionnaire was also used. A total of 1,760 participants including 920 males and 840 females MS students completed these scales. Regression analysis was conducted to study the effect of stress and coping resources on predicting each domain of the WHOQOL-BREF. RESULTS: The result showed that the stress of livelihood, academic difficulty and interpersonal relationship with family can jointly predict physical QOL. Most of the academic potential variables including knowledge, self-management, resilience/endurance, and teamwork are good predictor variables to psychological QOL. Social QOL is predicted by the overall interpersonal relationship. Finally, Environmental QOL can be predicted by overall interpersonal relationship, and the stress from academic difficulty, future development, and relationship with advisor. CONCLUSIONS: The battery of “Stress and Coping Resources” was used to predict graduate students’ quality of life measured by the WHOQOL-BREF.  The result showed that the subscales of stress and coping resources did predicted graduate students’ quality of life in various ways. Further study can be conducted to examine the mediate/moderate effect of coping resources on predicting QOL.