OBJECTIVES: The safety and effectiveness of Thermal Massage Therapy for the Treatment of Dry Eye Syndrome as a technology for treatment of dry eye symptom by stimulation of the obstructed meibomian glands through application of heat and vibration to the areas around the eyelids and the eyes were assessed. METHODS: For information search for systematic review considerations on Thermal Massage Therapy for the Treatment of Dry Eye Syndrome, 8 domestic databases including Korea Med and overseas databases including Ovid-Medline, Ovid-Embase and Cochrane Library were used. A total of 107 literatures were searched through search strategy. As the result, a total of 3 domestic and overseas literatures were included in the final assessment by applying the criteria for selection and exclusion to the 74 literatures after having excluded 33 overlappingly searched literatures. Each of the stages from literature search to application of selection standards and extraction of data were carried out independently by 2 assessors under the deliberation by the Sub-committee. Tools of Scottish Intercollegiate Guidelines Network (SIGN) were used for assessment of the quality of literature. RESULTS: Regarding the safety of the Thermal Massage Therapy for the Treatment of Dry Eye Syndrome, 3 literature reported conjunctivitis, temporary visual impairment, headache and abnormality in the area of contact as the procedure related complications or side effects. The effectiveness of the Thermal Massage Therapy for the Treatment of Dry Eye Syndrome was assessed by means of the ocular surface disease index (OSDI), break-up time (BUT), schirmer tear test (STT) and osmotic pressure of tear on the basis of 3 literatures. CONCLUSIONS: Thermal Massage Therapy for the Treatment of Dry Eye Syndrome was assessed as a safe and effective technology capable of improving the dry eye symptom by alleviating the obstructed meibomian glands through application of heat and vibration to the areas the eyes.