OBJECTIVES: Health Technology Assessment (HTA) is an integral part of modern health care system of developed countries. It is carried out to study decision-making and policy-making in health care based on objective information and evidence base. In Ukraine HTA reports are the one of the sources of evidence-based medicine which are used to develop medical and technological documents on standardization of medical care. METHODS: The introduction of HTA in Ukraine requires its own methodology. For the development of this methodology a systematic review of the literature for HTA was performed. The sources were analyzed for the possibility of adaptation in Ukraine. RESULTS: On the basis of the detected data, and based on the knowledge gained from ISPOR distance learning and short courses an instruction was designed to conduct analytical work with sources of scientific information on the possible inclusion of drugs to medical and technological documents. Several types of analytical work were included in the instruction: - Analytical work with sources of scientific information on the possible inclusion of drugs to medical and technological documents; - Systematic search of information sources; - Construction of tables of evidence; - Transferal of ready HTA reports to the national health system; - Conducting of HTA reports. CONCLUSIONS: Introduction of the system of medical technology assessment is a multilevel process that requires creation of appropriate scientific and technical base, training of qualified specialists and amendment of relevant regulations. An important component of this process is the exchange of experience and knowledge in this area through access to networks such as INAHTA, HTAi, EUnetHTA, and others.