SOCIETAL BURDEN AND IMPACT ON HEALTH RELATED QUALITY OF LIFE (HRQOL) OF NON-SMALL CELL LUNG CANCER (NSCLC) IN EUROPE
Author(s)
Enstone A1, Panter C1, Manley Daumont M2, Miles R1
1Adelphi Values Ltd, Bollington, UK, 2Bristol-Myers Squibb, Paris, France
Presentation Documents
OBJECTIVES: NSCLC accounts for approximately 85% of lung cancers globally and is associated with poor prognosis and a substantial burden to patients, societies and economies. Two systematic literature reviews (SLRs) were conducted to explore NSCLC and the associated societal burden (indirect and direct costs; SLR1) and impacts on patient HRQoL (SLR2) across Europe. METHODS: Both SLRs were conducted using the OVID search engine and reviewed: Medline® in process (PubMed) and Embase (OVID) for SLR 1 and 2, EconLit (EBSCOhost) and NHS Economic Evaluation Database for SLR1, and PsycINFO for SLR2. Searches were limited to human studies, English language and the past 10 years (July 2004 to July 2014 [SLR1] and June 2014 [SLR2]). Additional pragmatic searches were conducted of oncology organisation websites and conference proceedings of the American Society of Clinical Oncology (ASCO) Annual Meetings (2009–2014). RESULTS: Six publications on indirect costs (including lost productivity) and 18 on direct costs were identified through SLR1. Indirect costs were high in relation to total costs. Reporting of direct costs was diverse; in-patient stay, diagnostic/staging and treatment costs including medication and surgery were identified as major cost drivers. SLR2 identified 59 publications; HRQoL was reduced in patients with NSCLC when compared to the general population. Specific domains affected included emotional functioning (notably, depression and anxiety) and physical functioning. Generally, impacts were more unfavourable for patients with late-stage or progressive NSCLC and those receiving later lines of treatment. CONCLUSIONS: Data suggest the societal burden of NSCLC is substantial; however heterogeneity in study designs, reporting and evaluation methods limit cost comparisons. While NSCLC differentially impacts domains of HRQoL, the impact on daily activities, work, cognitive function and social functioning was not commonly reported. Further research to explore particular HRQoL domains and quantify the societal burden of NSCLC is ongoing.
Conference/Value in Health Info
2015-11, ISPOR Europe 2015, Milan, Italy
Value in Health, Vol. 18, No. 7 (November 2015)
Code
PRM47
Topic
Economic Evaluation, Methodological & Statistical Research
Topic Subcategory
Cost/Cost of Illness/Resource Use Studies, PRO & Related Methods
Disease
Oncology