OBJECTIVES: Primary care physicians (PCPs) play a key role in France in the prescription and administration of recommended vaccines. Uneven vaccination coverage in vulnerable populations appeals for specific interventions to be designed to address existing barriers faced by targeted groups of PCPs. The ‘Determinant of Intentions of VAccination’ (DIVA©) questionnaire was developed to assess PCPs’ attitudes and beliefs toward vaccination. The objectives of the study were to define the scoring rules and to assess the measurement properties of the DIVA questionnaire. METHODS: A cross-sectional study was conducted in France with PCPs to define the scoring of DIVA and to assess its measurement properties. PCPs had to complete the DIVA questionnaire in to any of the six vaccine-preventable diseases (VPD) they were randomly assigned (measles, pertussis, pneumococcus infection, seasonal influenza, HVP infection and tetanus). Internal consistency reliability and known groups validity were assessed. RESULTS: DIVA was completed by 1,069 PCPs (mean age 48; 58% male), with very good quality of completion (90% of questionnaires with no missing item). One redundant item was removed from the questionnaire. The final DIVA was composed of 55 items, grouped into six thematic domains covering disease, vaccine, information, organisation, consultation, and PCP experience, and one domain assessing PCP’s engagement. The Engagement score showed very good internal consistency reliability across the six VPD (0.80≤Cronbach’s alpha<0.90). The Rasch model validated the number, content and modalities of items of the Engagement domain. The six thematic scores showed overall good known groups validity. CONCLUSIONS: DIVA is a valid and reliable measure to assess PCPs’ engagement toward vaccination, as well as the specific barriers they face in various VPD. DIVA might help to define specific interventions aimed at improving PCPs vaccination activity, and can serve as an outcome measure to assess the impact of such interventions.