OBJECTIVES: To assess the prevalence of self-medication and its reason among Postgraduate Pharmacy students. METHODS: This cross-sectional study was conducted among Postgraduate Pharmacy students of NIPER, Mohali. Study duration was six months period of time (Nov. 2014 to Apr. 2015). Participants who were willing to participate in the study were included. Participants who had not completed or did not return back the questionnaire were excluded. Data collection was based on pre-designed questionnaire containing close ended questions. Participants were assured of their confidentiality and anonymity. Data collected was analysed using IBM SPSS for windows statistical software version 20 (SPSS Inc, Chicago, USA). Data was presented using descriptive statistics (i.e. numbers, percentages).  RESULTS: A total of 450 questionnaires were administered to the respondent. After exclusion, finally 378 respondents were included. Majority of the respondents (94%) accepted their habit of practicing self-medication. In this study, 86% of the respondents were found to have habit of advising medicines to others, while 70% respondents tried medicines according to their friend’s suggestion. Most common reason cited for self-medication was found to be convenience (42%), followed by quick relief (21%), time saving (13%), economical (10%) and others (14%). CONCLUSIONS: Self-medication is highly prevalent in pharmacy students. One potential reason could be the easy availability of wide range of drugs without prescription.