OBJECTIVES: This study aimed to evaluate the prescription pattern of outpatient department of teaching hospital  (Bolan Medical Complex Hospital) Quetta, Pakistan. METHODS: A retrospective study was conducted in outpatient department of teaching hospital (Bolan Medical Complex Hospital) Quetta,  Pakistan. Four hundred and eighty prescription were selected from a record of two months (i.e. July and August, 2015) and the prescription parameters were recorded on a data collection form. There are 13 components of the prescription which classified as 5 different domains. The data was analyzed for adherence to prescription format and rationality. Statistical analysis was done by using SPSS version 20 RESULTS: Total of 480 prescription were included randomly from the available record. Four hundred and forty (91.7%) prescriptions lack the information of patient, where 129 (26.9%) has incomplete prescriber information. Majority of prescriptions 418 (87.1%) has absence of patients present complaint, 452 (94.2%) prescriptions have not any investigation record, where 403 (84.01%) prescriptions are without having diagnosis notes. The average number of drugs per prescription was found as 3.3 and presence of antibiotic in prescriptions was 74% (n=355). Most number of medicines in a single prescription was three medicines in single prescription present which is account of  50% (n=240) prescriptions.  CONCLUSIONS: The study revealed that the prescription from out patients department of teaching hospitals was not following the proper format and medicines prescribed are irrational. The prescriber should be made aware of the rational use of drugs through continued medical education (CME).