OBJECTIVES: Social Listening through digital media may offer a unique opportunity to enhance traditional pharmacovigilance strategies. The objective of this pilot study was to evaluate the breadth of pharmaceutical products and vaccines most commonly discussed on Facebook and Twitter and how these data may inform future research in this area. METHODS: Publically available Facebook and Twitter posts containing at least one product and one adverse event keyword were collected, de-identified, and standardized using a vernacular to MedDRA dictionary. RESULTS: There were a total of 1,410,819 posts containing products and events, 265,838 (19%) from Facebook and 1,144,981 (81%) from Twitter. The top 10 products accounted for 940,666 (67%) of the total posts in Facebook and Twitter combined. The top 25 accounted for 1,180,040 (84%), the top 50 for 1,285,836 (91%), and the top 100 for 1,245,010 (95%) of the total posts. The top 10 products (diphenhydramine, flu vaccine, dextroamphetamine, codeine, morphine, ibuprofen, alprazolam, acetaminophen, oxycodone, and zolpidem) were comprised of six controlled substances, three over-the-counter (OTC) products, and one class of vaccine. Of the top 50 products, controlled substances accounted for 32%, OTC products for 24%, and vaccines for 10%. CONCLUSIONS: Review of publically available data over the past two years from two popular social media sites, Facebook and Twitter, offers a high number of potential adverse events for further evaluation. Social listening may be potentially valuable as a supplement to traditional pharmacovigilance practices, particularly for controlled substances, over-the-counter products, and vaccines. These initial findings warrant more research and a closer inspection as to the nature of these posts.