OBJECTIVES: Patient-reported outcomes (PRO) provide a more comprehensive picture of patients’ quality of life than do mere physicians’ ratings. Electronic data collection of PRO offers several advantages and allows assessments at patients’ homes as well. This study reports on patients’ internet use, their attitudes towards electronic and web-based PRO assessment (clinic-ePRO and home-ePRO) and the feasibility of these two assessment modes. METHODS: At the Medical University of Innsbruck and Kufstein County Hospital, cancer patients who participated in clinic-ePRO/home-ePRO were asked to complete a comprehensive evaluation form on their internet usage, attitudes towards and the feasibility of routine clinic-ePRO/home-ePRO with the Computer-based Health Evaluation System (CHES) software. RESULTS: In total, 158 patients completed the evaluation form. Most patients expressed willingness to complete routine clinic-ePRO (92.3%)/home-ePRO (70%) assessments in the future and to discuss such data with attending physicians (82.2%). The CHES software for home-ePRO was preferred over phone interviews by 95.7% of patients and 72.7% experienced it as easy to use. Only a few minor suggestions for improvement were made. Overall satisfaction with home-ePRO was high with an average rating of 9.1 points (range 5-10 points). However, there became an age bias apparent, as participating patients were approximately ten years younger than those refusing clinic-ePRO/home-ePRO. CONCLUSIONS: The use of clinic-ePRO/home-ePRO was in general shown to be feasible and well accepted. However, to be more inclusive in the implementation of clinic-ePRO/home-ePRO, educational programs concerning their particular benefit in oncology practice potentially could enhance patients’ attitudes towards, and consequently their acceptance of and compliance with electronic PRO assessments.