OBJECTIVES: Calprotectin is a calcium binding protein released by neutrophils associated with inflammation. A recent systematic review has confirmed the value of testing faecal calprotectin to help distinguish between organic (inflammatory bowel disease - IBD) and non-organic gastrointestinal disease (irritable bowel syndrome - IBS). National Institute of Clinical Excellence (NICE), UK guidelines were thus written to guide general practitioners (GPs) in excluding IBD and to achieve savings by reducing the number of referrals to secondary care. We aimed to determine the 12 month clinical outcomes of patients undergoing FC testing in primary and secondary care settings. METHODS: RESULTS: