OBJECTIVES: To assess medical technologies in order to increase efficiency and reduce the cost of thyroid disease treatment.  METHODS: We made the retrospective analysis of 81 patients's medical records with hypothyroidism that were hospitalized to the endocrinology department of Ternopil University Hospital (Jan-Dec 2012). The cost of replacement therapy with levothyroxine drugs, which were preferred in practice, was analyzed. We also checked the appropriateness of diagnostics and specialist consultations according to the Protocol of medical care for patients with endocrine system disorders. RESULTS: The result of retrospective analysis of 81 patients's medical records with hypothyroidism showed that all patients received replacement therapy by levothyroxine. Among them 74 patients were treated with drugs of Ukrainian production while 7 patients were taking medicine of foreign manufacturer. The cost of pharmacotherapy with foreign medicines was 125% more expensive compare to Ukrainian drugs. When comparing diagnostics and specialists consultations with a Protocol of medical care for patients with endocrine system disorders we have established compliance. However, given the prevalence of complications of underlying disease by cardiovascular system disorders (in 100% of patients), we consider it necessary to add cardiologist consultation to Protocol. CONCLUSIONS: It is advisable to use domestic drugs in pharmacotherapy of hypothyroidism. Cardiologist consultation should be added to Protocol of medical care for patients with hypothyroidism.