OBJECTIVES: To evaluate the clinical and the economic outcomes of a personalized care model (PCM) in diabetes mellitus (DM) supported by information and communications technology (ICT) in the Spanish National Health System (NHS). METHODS: We evaluated a PCM in DM proposed by a group of European experts based on 6 steps: 1.Structured education; 2.Structured self-monitoring of blood glucose (SMBG); 3.Structured documentation; 4.Structured data analysis; 5.Personalized treatment; 6.Evaluation of results. A literature review was made to assess the results of interventions made within the NHS that used the PCM described. Interventions evaluating type 2 DM (T2DM), type 1 DM (T1DM) and gestational DM were included. The health outcomes measured were the variation in HbAthe percentage of controlled patients, the body mass index and the body weight. The analysis was made from the payer's perspective, considering the direct costs related to the pathology (€ 2015). Costs evaluated were: hospital costs, outpatient visits costs, primary care costs, emergency care costs and SMBG costs. RESULTS: The review carried out showed that the introduction of this PCM in T2DM would result in an increase of up to 18% in controlled patients (HbA <7%) compared with the current model (follow-up of 12 months). The expected reduction in HbAwould be about -0.5%. The implementation of the PCM proposed would reduce the cost of T2DM by about 12% compared with the current model with reductions of up to 30% in the cost for outpatient visits. The expected reduction in total direct costs was approximately 12% in T1DM and around 14% in gestational DM. CONCLUSIONS: The implementation of a PCM in DM with ICT support improved or provided equal disease control compared with conventional care and reduced the high costs associated with diabetes. ICT enables adaption and changes in the current model of care and potentiate self-management strategies.