EFFICACY OF THE MICA ANTIBODY FOR TRANSPLANT PATIENTS

Author(s)

MO J
National Evidence-based Healthcare Collaborating Agency, SEOUL, South Korea

OBJECTIVES: MICA antibody identification is a test performed on transplant patients to check for the presence of donor-specific MICA for the purpose of predicting the incidence of organ rejection among transplant patients. The purpose of this assessment was to evaluate the effectiveness. METHODS: The literature search was performed using 8domestic research databases and 3core databases. A total of 9papers that remained. Each of the stages from literature search to application of selection criteria and data extraction was independently by 2researcher. The SIGN was used for the quality assessment. RESULTS: There were 5studies reporting on the medical results of kidney transplant patients. 2of the studies reported no significant differences in the graft survival rate and incidence of organ rejection(p=.67). There were 3studies reporting of heart transplant patients. There was one study reporting of lung transplant patients. The incidence of organ rejection was reported to be 42.0%(p=ns). CONCLUSIONS: MICA Identification lacked clinical effectiveness for the following reasons: i)there were no significant differences in the graft survival rate and incidence of organ rejection; ii)it is difficult to determine whether the different results for the graft survival rate and incidence of organ rejection reported.

Conference/Value in Health Info

2015-11, ISPOR Europe 2015, Milan, Italy

Value in Health, Vol. 18, No. 7 (November 2015)

Code

PSY3

Topic

Clinical Outcomes, Epidemiology & Public Health

Topic Subcategory

Comparative Effectiveness or Efficacy, Disease Classification & Coding, Relating Intermediate to Long-term Outcomes, Safety & Pharmacoepidemiology

Disease

Systemic Disorders/Conditions

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