OBJECTIVES: Chronic urticaria (CU) (or chronic hives) can be inducible or spontaneous (also known as idiopathic urticaria) (CSU/CIU). Data supporting the impact of CSU/CIU on patients and comparison with other dermatological diseases are scarce. This study evaluated economic burden associated with CU relative to psoriasis (PsO) overall and different severity levels of PsO among the adults in 5 European (France, Germany, Italy, Spain and UK) countries. METHODS: Data from patients diagnosed with chronic hives (proxy for CSU) and PsO were collected in the National Health and Wellness Survey (NHWS). Outcome measures included the Work Productivity and Activity Impairment (WPAI) questionnaire and self-reported healthcare use in prior 6 months. Generalized linear models with different link functions were used to compare patients with CU vs. overall PsO (includes all severity levels) and CU vs. moderate-severe-PsO, controlling for patient characteristics. RESULTS: Study included 769 CU patients and 7,857 PsO patients (26.9% moderate-severe). CU patients reported non-significant higher rate ratio (RR) of absenteeism (RR=1.31), presenteeism (1.15) and overall work impairment (1.15) than overall PsO, however, activity impairment was significantly higher among CU patients (1.21; p<0.05). The rates of work and activity impairment were similar between CU and moderate-severe-PsO patients (RR: absenteeism; 0.99, presenteeism; 0.97, overall work impairment; 0.97 and activity impairment; 1.08) (all p=NS). Rate of healthcare visits were higher among CU than overall PsO (RR: HCP visits; 1.16, ER visits; 2.13, Hospitalizations; 1.94, all p<0.001) and also than moderate-severe-PsO patients (RR: HCP visits;1.07, ER visits;1.77, Hospitalizations;1.47, all p<0.001). CONCLUSIONS: Patients with CU and PsO report a similar negative impact on work ability. Compared to overall PsO patients with CU have a significantly higher impact on daily activities and non-significant higher impairment on work components. The impact on work and activities is similar among CU and moderate-severe PsO. CU patients report significantly higher use of medical resources than Pso.