OBJECTIVES: Outpatient parenteral antimicrobial therapy (OPAT) is a strategic delivery modality of care however cost-analysis should support decision-making. This study was performed in order to analyze the economic studies related to OPAT METHODS: a systematic review was performed with the following search terms: outpatient (Population), anti-infective agents, infusion therapy or home care (Intervention), inpatient (Comparator), complications related to infection, cure, readmission, catheter infection, death (Outcome), and economic analysis (Study design). Publications were searched from health sciences databases (MEDLINE, Embase, The Cochrane Library, Lilacs, Bireme, Medscape, Trip database, Web of Science), health technology evaluation sites and gray literature (dissertation abstracts), independently of publication´s year or idiom. Three different reviewers evaluated the manuscripts in a systematic progressive process beginning from title followed by abstract and complete reading for quality of evidence. RESULTS: