OBJECTIVES: Between 10 and 29% of lung cancer (LC) are supposed to be attributable to occupational exposures. However, LC of occupational origin remains under-reported. To improve the identification and compensation of occupational LC, we implemented at the Léon-Bérard Cancer Centre, a questionnaire-based process to systematically identify LC patients potentially exposed at the workplace and to be seen in an “occupational cancer” consultation. Selection was based on patients’ reporting of exposure to carcinogens or potentially exposed occupations. The aim of this study was to assess the cost of this innovative program. METHODS: The cost assessment was performed prospectively. Three situations were analyzed: questionnaire returned by the patient (up to one reminder), consultation required (situation 1), questionnaire returned (up to one reminder), no consultation required (situation 2), questionnaire not returned (up to one reminder) (situation 3). Cost calculations were strictly based on a micro costing approach according to the hospitals’ point of view. Data on consumption of resources were collected from the questionnaire administration until the physician evaluation and occupational cancer declaration if any. Uncertainty was captured by one-way and probabilistic sensitivity analyses using a non-parametric bootstrap method. All costs were given in 2014 euros. RESULTS: