OBJECTIVES: This systematic review aims to summarise and critically appraise the current evidence for the cost effectiveness of multidisciplinary pain management services in managing chronic back pain. METHODS:  Electronic search  was conducted in three clinical databases, which include: MEDLINE, EMBASE and PsycINFO (using Ovid interface) from their inception to March 2015.Other databases such NHS Economic Evaluation Database (NHS EED) and Health Technology Assessment Database (HTA) in the Centre for Reviews and Dissemination (CRD), were also explored to retrieve economic evaluation studies.  The quality of randomised clinical trials was assessed by Cochrane Back Review Group (CBRG) risk assessment tool. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist was used to assess the methodological quality of reporting economic studies. RESULTS:  Five studies fulfilled our eligibility criteria. All of them were economic evaluations alongside randomised clinical trials. Two studies were from Norway, two from the Netherlands and one from the United Kingdom. These studies were published between 2002-2014. Two out of Five studies were considered having “low risk of bias). Three cost effectiveness studies showed that multidisciplinary pain management services were cost effective compared with usual care and surgery. The remaining studies showed that these services were not cost effective.  CONCLUSIONS: Current evidence is inadequate to determine the cost effectiveness of multidisciplinary pain management services due to the variability of the interventions, comparators and outcomes.