CLINICAL RESPONSES IN JOINT AND SKIN OUTCOMES AND PATIENT-REPORTED OUTCOMES ARE ASSOCIATED WITH INCREASED PRODUCTIVITY IN THE WORKPLACE AND AT HOME IN PSORIATIC ARTHRITIS PATIENTS TREATED WITH CERTOLIZUMAB PEGOL

Author(s)

Kavanaugh A1, Gladman D2, van der Heijde D3, Purcaru O4, Mease PJ5
1University of California, San Diego School of Medicine, La Jolla, CA, USA, 2University of Toronto, Toronto, ON, Canada, 3Leiden University Medical Center, Leiden, The Netherlands, 4UCB Pharma, Brussels, Belgium, 5Swedish Medical Center and University of Washington, Seattle, WA, USA

OBJECTIVES: To evaluate the association between improvements in clinical and patient-reported outcomes (PROs) and improvements in workplace and household productivity in psoriatic arthritis (PsA) patients treated with certolizumab pegol (CZP). METHODS: Analyses used Week (Wk) 24 data from the double-blind, placebo-controlled period of RAPID-PsA (NCT01087788), for patients originally randomized to CZP. Responders and non-responders for clinical outcomes and PROs were compared in terms of change from baseline (CFB) in workplace and household productivity, assessed with the arthritis-specific Work Productivity Survey (WPS). Groups were compared using a non-parametric bootstrap-t method. LOCF was used for WPS outcomes; NRI for clinical outcomes and PRO MCIDs. RESULTS: CONCLUSIONS: Achievement of disease remission, clinically meaningful improvements in joint and skin outcomes and symptom relief were associated with increased workplace and household productivity in PsA patients treated with CZP.

Conference/Value in Health Info

2015-11, ISPOR Europe 2015, Milan, Italy

Value in Health, Vol. 18, No. 7 (November 2015)

Code

PMS114

Topic

Economic Evaluation

Topic Subcategory

Work & Home Productivity - Indirect Costs

Disease

Musculoskeletal Disorders

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