OBJECTIVES: Based on the data of the Hungarian Central Statistical Office the prevalence of oncological patients in Hungary is growing due to the modern diagnostic devices, the effectiveness of diagnostic screening methods and the increasing life expectancy. This study aims to assess information about the change in the mortality rate in the relevant patient population during the last decades. METHODS: This retrospective study was based on the National Health Insurance Fund Administration financing database. The study period spanned between 01.01.2005 and 12.31.2014. Several oncological fields were investigated: lung cancer (ICD C34), prostate cancer (ICD C61), kidney cancer (BNO C64-C65), breast cancer (ICD C50), haematopoietic and lymphatic system cancer (ICD C81-85, C88, C90-96) and colorectal cancer (ICD C18-C20). The trends in overall survival (OS) have been computed and compared for each subgroups using Cox proportional hazard models. RESULTS: In general there was found that age, metastatic stage and comorbidities were the most relevant covariates in all groups. Analysing trends of mortality there is a difference between patients who were diagnosed in 2007 comparing to those who were diagnosed in 2011. CONCLUSIONS: The magnitude of the fitted trends could be very different, the precise reasons of the differences and the difference of cost, the relative risk of the mortality, and the comorbidity effects within the variant disease groups should be further investigated. The applied framework methods can serve both direct comparison and forecasting models in care management, e.g. Disability-Adjusted Life Year, Quality-Adjusted Life Years, Years of Potential Life Lost.