OBJECTIVES: Oncology medicines reimbursed in France have a fixed price whereas the benefits vary across patient groups. Pricing models aligned to the benefit for patients open an interesting concept, but they need to be supported by reliable and standardised metrics aligned with heath authorities ‘expectation. The Personalised Reimbursement Models (PRM) pilots aim to establish an infrastructure validated by the National Data Privacy Committee to collect existing data of metastatic breast cancer patients (mBC) taking trastuzumab and leverage preliminary analytics to evaluate the relevance of this approach.  METHODS: mBC patients at 14 pilots centres recorded in the Electronic Pharmacy Record (EPR) system with at least one trastuzumab claim between January 2011 to October 2014 that were not enrolled in a clinical trial were selected. Data related to demographics, disease description, drug usage and clinical outcomes were collected in the EPR. These data were controlled, cleaned and centralised in an anonymous and secure way through an accredited hosting provider. RESULTS: