OBJECTIVES: Bioabsorbable drug-eluting sinus implants (BDESI) inserted during endoscopic sinus surgery (ESS) have been shown to improve post-operative outcomes in the management of refractory chronic rhinosinusitis (CRS) through reduced post-operative scarring, inflammation, polyposis and middle turbinate lateralization. This study estimated the incremental budgetary impact of incorporating BDESI in CRS patients undergoing ESS. METHODS: A budget impact model (following ISPOR’s Good Practice Report) was developed from the perspective of the United States payor/self-insured employer. The model was created to be dynamic and adaptable to different countries. Estimates of the prevalence of CRS; rates of ESS; and effectiveness outcomes; along with direct and indirect costs from CRS were obtained from a best-evidence systematic review of the published literature. A total population of 1.5 million members was used for the analysis. All cost data obtained from the published literature were adjusted to April 2015 US dollars using the medical care component of the Consumer Price Index. The comparator groups were ESS with BDESI compared to the current clinical peri-/ post-operative care. Primary outcome was the incremental budget impact reported using per-member-per-month (PMPM) costs. Scenario-based, probabilistic, and one-way sensitivity analyses were performed. RESULTS: For a US payor/self-insured employer health plan of 1.5 million members, the incremental PMPM impact of BDESI was estimated to range from -$0.009 to $0.09. The results varied based on the parameters included in the individual scenario. Sensitivity analyses revealed these findings to be robust to specified parameter value ranges. CONCLUSIONS: Previously published studies have documented the clinical benefits of BDESI. This study has demonstrated the use of BDESI during ESS procedures has negligible impact on the healthcare budget. Additional research is necessary to determine the budget impact for different countries based on the same factors described within this analysis.