OBJECTIVES: Mandatory generic substitution is valid since December 2011. It was one of the key cost-containment measures at the field of drug policy. We provided research on statistically selected sample of patients in Slovakia last year and this year we present results from medical doctors’ and pharmacists’ population to detect current attitude, knowledge and believes toward generic substitution (GS).  METHODS: Based on descriptive statistic methods we performed explorative research analysis. We created special questionnaire for medical doctors (MD) and pharmacists (P) and distributed it in selected regions in Slovakia. We evaluated 131 (MD) and 138 (P) out of 702 collected questionnaires. Research was performed in 2014 and 67% MDs and 68% of pharmacists were younger than 50. RESULTS: Only 2% MDs and 9% pharmacists indicated price of drug as key parameter for treatment recommendation with generic drug. In contrary, 89% of MDs and 69% of pharmacists indicated their own experience with treatment as key factor for treatment recommendation. One third (34%) of MDs did not offer in last three month any generic drug to their patients compared to pharmacists where 100% offered generic substitution. Different situation was noticed in the relationship with patients where 56% MDs responded that patients did not ask for cheaper generic alternative compared to pharmacists where only 17% of patients did not ask for cheaper drug. 40% of MDs and 37% of pharmacists indicated distrust towards quality, effectiveness and safety of generics compared to original molecules. Bivariate analysis also showed significant distrusts among MDs/P towards generic substitution (p<0,001) and we also found significant correlation between age of MDs/P and attitude towards safety, quality and effectiveness of generics. CONCLUSIONS: Based on our research among MDs and pharmacists we conclude that generic substitution is already part of their daily ruotine, but there is still significant negative perception that should be further evaluated.