OBJECTIVES: This study aimed to evaluate the level of knowledge and awareness of asthma among private and government schoolsteachers in urban area of Quetta. METHODS: A cross-sectional study was conducted to assess thelevel of knowledge and awareness of asthma among teachers of 12 different schools by administering a pre-validated questionnaire which was developed in English and then translated into Urdu by using standard translating procedure which consist of 18 questions to evaluate the knowledge and awareness.Convenient sampling technique was used and around 330 questionnairewere distributed among teachers. Descriptive analysis to demonstrate patients’ demographics. Knowledge score is calculated as 18 as there are 18 questions with one score for each right answer and total score is divided in two grades with low grade of knowledge (0-9 score) and high grade score (10-18 score). Inferential statistics (Mann-Whitney and Kruskal Wallis test, p<0.05) were used to differentiate or relate the study variables. RESULTS: A total of 330 questionnaire were distributed with the response rate of 90%. One hundred ninety nine (64.4%) were from Private schools. Majority of respondents 114 (38.4%) belong to age 25-31 years.One hundred and ninety (64.0%) teachers were female. The graduates were 58 (19.5%). Majority of respondents 191 (64.6%) have experience of 1-5 years in teaching. One hundred and seventy two (57.7%) having good knowledge regarding asthma. It is also noted that knowledge of female teachers is good as compared to male teachers. Gender dominantly affect (P <0.05) the knowledge of the respondents.  CONCLUSIONS: This study highlights that although majority of school teachers having poor knowledge regarding asthma. It is advised to train and educate the school teachers to recognize the early symptoms of asthma.