"EFFICACY AND SAFETY BARIATRIC SURGERY VS. CLINICAL TREATMENT IN CONTROL OF LEVELS GLYCEMIC AND REMISSION DIABETES MELLITUS TYPE II IN PATIENTS OBESE"

Author(s)

Zanghelini F1, Buehler AM2, Pereira Td2
1Universidade Federal de Pernambuco, Recife, Brazil, 2Hospital Alemão Oswaldo Cruz, São Paulo, Brazil

OBJECTIVES: Evaluate the results on the efficacy and safety of bariatric surgery vs. medical treatment in remission of type 2 diabetes mellitus (T2DM) and control of blood glucose levels in patients with Body Mass Index ≥ 30. METHODS: Following the methodological guidelines for the development of PTC Ministry of Health, was first drafted the guiding question of the study through the PICO, then a search was conducted in the main databases (PubMed, Embase, Cochrane, Lilacs and CRD). Each study recovered in the databases was selected and evaluated by two independent researchers, their inconsistencies resolved by consensus, when there was no consensus, the assessment of a third investigator was requested. RESULTS: Bariatric surgery showed to be effective and safe in reducing glycated hemoglobin levels, fasting blood glucose levels as well as the augmenting the chances of remission of type II diabetes in obese patients. CONCLUSIONS: However, the variability in the magnitude of the results indicated the need for new data from the 18 ongoing clinical trials. In other words, the technology "bariatric surgery" is efficacious as a whole, but there is a high variability in the treatment effect, depending of surgical technique.

Conference/Value in Health Info

2015-11, ISPOR Europe 2015, Milan, Italy

Value in Health, Vol. 18, No. 7 (November 2015)

Code

PDB12

Topic

Clinical Outcomes, Epidemiology & Public Health

Topic Subcategory

Comparative Effectiveness or Efficacy, Safety & Pharmacoepidemiology

Disease

Diabetes/Endocrine/Metabolic Disorders

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