As a developing country, Egypt has long suffered negative outcomes from irrational drug dispensing practices. This affected health economics adversely and increased the burden of antibiotic resistance. With limited research data on this specific area in Egypt, it becomes imperative to guide the researchers to potential adverse effects of over-the-counter dispensing on antibiotic resistance prevalence. This research aims to define the flaws in antibiotic dispensing in Egypt and its impact on the access to antibiotics.  Spending on pharmaceuticals in Egypt constitutes 34% of the total health care spending. The Ministry of Health and Population has enforced several laws prohibiting over-the-counter dispensing of drugs. However, there is limited evidence on the effectiveness of those regulations on inappropriate dispensing. Literature review revealed that only one report that dates back to 1998 addressed this area of inquiry. Analysis of 1174 dispensed products in 25 different districted pharmacies in Alexandria showed that 60% of medications dispensed were without a prescription or a pharmacist recommendation. Among those products, there were 98 different antibiotic products of which 42% were dispensed without a prescription. Over all, Egypt suffers a high percentage of over-the-counter dispensing of drugs with little studies paying attention to this aspect in terms of antibiotic resistance patterns. Despite enforced laws prohibiting over-the-counter dispensing of drugs, further interventions are required. More strict laws must apply to pharmacists who do not comply with the official regulations of drug dispensing. Further studies should inquire into non-optimal dispensing practices. Educational campaigns for patients to increase their level of awareness are crucial to decrease wasteful drug spending and ensure approximate containment of newly emerging antibiotic resistance in the near future.