OBJECTIVES: To evaluate resource use and cost determinants associated with hospitalization of Crohn’s disease patients. METHODS: All patients hospitalized at our institution from 01.01.2010 to 30.11.2011 were analyzed. We extracted all inpatient records whose hospital discharge abstracts included ICD-10 code K50 consistent with the diagnosis of Crohn’s disease. Statistical analysis was performed using the chi-square test. RESULTS: Of 4028 all hospital admissions 315 belonged to Crohn’s disease. There were 150 females and 145 males, mean patient age was 37.8 years. 52 (16.5%) patients were hospitalized more than once therefore the total number of patients hospitalized was 220. The mean length of stay was 5.1 days. There were 42 hospitalizations in order to administer anti-TNF drug; these were excluded from further analysis. The distribution of resource use was as follows: plain abdominal radiograph (6.2% of hospitalizations), small bowel pass through (5.9%), chest x-ray (36.3%), abdominal ultrasound (76.6%), CT (13.9%), CT enteroclysis (25.3%), MRI (4.8%), upper gastrointestinal endoscopy (52.7%), colonoscopy (55.7%). The drug use was as follows: sulfasalazine (22.3%), mesalamine (55.7%), azathioprine (26.7%), steroids (15.8%), antibiotics (23.8%). 11 cases required total parenteral nutrition. The length of stay, resource and drug use were dependent on disease activity. 65.5% patients with CRP ≤ 10.0 mg/dl were hospitalized for not more than 5 days. Patients in whom antibiotics were used accounted for 23.8% of cases and 40% of costs.  CONCLUSIONS: The structure of inpatient treatment costs for CD has been demonstrated for a Polish hospital. Direct medical costs are in relation with disease activity.