OBJECTIVES: To assess the impact of Rheumatoid Arthritis (RA) and its treatment on health- related quality of life (HRQOL) of RA patients and identify factors predicting the risk of disability and their poor Quality of Life (QOL) METHODS: A observational cross-sectional study was carried out prospectively on 159 RA patients admitted in a tertiary care hospital. An interview questionnaire was used to collect data. Patients’ medical records were reviewed. For evaluating the quality of life and to assess functional disability in RA patients PROMIS-HAQ questionnaires were used. To measure the disease activity in patients with RA Disease Activity Score (DAS28) were used. Other outcome measures of disease activity were also used. RESULTS: Mean age at time of admission was 47.83±12.5SD years and 69.5% of patients were having rheumatoid factor positive. About 82.2% patients had active RA. The Mean scores  ± SDs on composite DAS28-ESR score was 4.9 ± 0.4 reflecting moderate disease activity and Mean HAQ-DI score was 2.3±0.3 indicating much functional impairment. The HRQOL of all the patients was significantly (P<0.05) impaired with a visual analogue scale equal to 56.7. Patients with active RA had poorer scores than patients in remission. Patient’s age, age at onset, disease duration, patient’s assessment of pain were significantly (P<0.05) associated with disease severity and functional impairment. Moreover, disease activity and functional disability measures were strongly associated with HRQOL measures. DAS28 score and family history of RA were the strongest predicators for functional impairment. HAQ-DI score was the only significant predictor for QOL of RA patients. CONCLUSIONS: HRQOL is an important measure in the regular assessment of the disease. Present study showed a significant increase in HAQ scores as the physical disability increased and a highly significant association between the DAS 28, as well as the HAQ scores of patients with active RA.