OBJECTIVES:  Patients’ living with HIV/AIDS perceptions of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns were assessed using the HAT-QOL. We explored the impact of socio-demographic profile on the quality of life domains. METHODS: Consenting outpatients who met criteria were consecutively selected. Socio-demographic characteristics of the patients were profiled. Health related quality of life was determined in the domains of Overall function, Life satisfaction, Health worries, Financial worries, Medication worries, HIV mastery, Disclosure worries, Provider trust, and Sexual function. Quality of life scores were computed on the standard scale of 0 - 100 and triangulated with a rated interval scale of 1-5 suited for quantitative analysis. Association between rated scores and each domain was explored using Students’ t-test and ANOVA at 95% confidence interval. RESULTS: Four hundred and seven (407) patients (74 males + 333 females) participated. Majority of the patients (147, 36.1%) aged 20 to 30 years and 239 (58.7%) were not married. Also, 338 (83.0%) earned below $1500 pa and 303 (74.4%) had basic education. HAT-QOL scores indicated: Overall function (89.96 ± 5.62); Life satisfaction (91.94 ± 3.62); Health worries (87.06 ± 4.28); Financial worries (81.00 ± 3.95); Medication worries (91.65 ± 4.47); HIV mastery (71.00 ± 3.11); Disclosure worries (27.50 ± 7.58); Provider trust (91.63 ± 1.96); and Sexual function (70.25 ± 3.52). Rated scores were in congruence with HAT-QOL scores. Provider trust was associated with gender, employment status, and educational level, (P <0.05). CONCLUSIONS: Patients reported satisfactory quality of life in the various domains except disclosure worries, indicating concerns for discrimination and stigmatization. Provider trust was associated with gender, employment status, and educational level. Sexual function was associated with gender and age of the patients.