OBJECTIVES: Although gout has been found to be associated with health-related quality of life (HRQoL), few studies have examined the burden of gout in the presence of concomitant cardiometabolic conditions. The present study evaluated the effect of gout on HRQoL and work productivity among patients with hypertension. METHODS: Data from the 2010 National Health and Wellness Survey were obtained for respondents ≥18 years who reported physician-diagnosed hypertension or BP levels ≥140/90 mm Hg (≥130/80 mm Hg for those with physician-diagnosed diabetes or CKD). Bivariate analysis was used to evaluate differences between patients with and without comorbid gout. Generalized linear models were used to evaluate productivity (using the WPAI) and HRQoL (using the PCS, MCS, and health utilities from the SF-12v2) differences. Because uric acid levels may influence other organ systems, core modeling did not include comorbidities other than osteoarthritis and depression as covariates. Sensitivity analyses controlled for the Charlson comorbidity index (CCI). RESULTS:  A total of 22,686 patients with hypertension met study eligibility requirements. 4.51% of patients reported having gout. These patients were older, more likely to be male, and have insurance through the VA (all ps<0.05). Patients with comorbid gout reported lower levels of MCS (47.25 vs. 48.93), PCS (39.06 vs. 43.78), and health utilities (0.68 vs. 0.73, all ps<0.05). For both PCS and health utilities, differences between groups exceeded clinically-meaningful cutoffs. Sensitivity analyses conducted on PCS and health utilities uncovered slightly smaller, but statistically significant and clinically-meaningful, effects (ps<.05). The effect of gout on overall work impairment (23.33% vs. 17.40% with and without comorbid gout, respectively) remained after controlling for CCI. Significantly greater impairment in daily activities (38.96% vs. 28.32%, p<0.05) was also observed among patients with comorbid gout. CONCLUSIONS: Results demonstrate that gout has significant and clinically-meaningful impact on work productivity, physical HRQoL and utilities independent of other health conditions.